Guideline for the classification of the acute emetogenic potential of antineoplastic medication in pediatric cancer patients Academic Article uri icon

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  • This guideline provides clinicians caring for children with an approach to assessing the acute emetogenic potential of antineoplastic therapies. It was developed by an international, inter-professional panel of clinicians and researchers using AGREE and CAN-ADAPTE methods. The emetogenicity of antineoplastic agents was evaluated and ranked as high, moderate, low, or minimal. The emetogenicity of multiple-agent and multiple-day antineoplastic therapy was also classified. Gaps in the evidence used to underpin the guideline recommendations were identified. The contribution of this guideline to the prevention of antineoplastic-induced nausea and vomiting in individual children about to receive antineoplastic therapy requires prospective evaluation.


  • Dupuis, L Lee
  • Boodhan, Sabrina
  • Sung, Lillian
  • Portwine, Carol
  • Hain, Richard
  • McCarthy, Patricia
  • Holdsworth, Mark

publication date

  • August 2011