Journal article
Sarcoplasmic reticulum Ca2+ pump mRNA stability in cardiac and smooth muscle: role of poly A+ tail length
Abstract
Transcripts of the sarco/endoplasmic reticulum Ca2+ pump SERCA2 are alternatively spliced to produce SERCA2a (expressed in left ventricular muscle (LVM)) and SERCA2b (in stomach smooth muscle (SSM)) mRNA that use different polyadenylation sequences. SERCA2 mRNA in LVM is more stable than in SSM. Here, we report that the SERCA2 poly A+ tail length in LVM (32 +/- 2 bases) is longer than in SSM (20 +/- 1). In the in vitro decay assays, the …
Authors
Nie L; Khan I; Misquitta CM; Grover AK
Journal
Cell Calcium, Vol. 35, No. 5, pp. 479–484
Publisher
Elsevier
Publication Date
May 2004
DOI
10.1016/j.ceca.2003.12.001
ISSN
0143-4160