Journal article
Influence of dichlorodiphenylchloroethylene on vascular endothelial growth factor and insulin-like growth factor in human and rat ovarian cells
Abstract
1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE, DDE), a metabolite of DDT is a persistent hormonally active environmental toxicant present in human serum and follicular fluid. The objective of this study was to investigate the effects of DDE on the expression of the ovarian vascular endothelial growth factor (VEGF) and insulin-like growth factor (IGF-1) in primary cultures of human granulosa cells and in the rat ovary. Granulosa cells …
Authors
Holloway AC; Petrik JJ; Younglai EV
Journal
Reproductive Toxicology, Vol. 24, No. 3-4, pp. 359–364
Publisher
Elsevier
Publication Date
11 2007
DOI
10.1016/j.reprotox.2007.05.003
ISSN
0890-6238