Journal article
Design and rationale of the TOTAL trial: A randomized trial of routine aspiration ThrOmbecTomy with percutaneous coronary intervention (PCI) versus PCI ALone in patients with ST-elevation myocardial infarction undergoing primary PCI
Abstract
BACKGROUND: A major limitation of primary percutaneous coronary intervention (PPCI) for the treatment of ST-elevation myocardial infarction (STEMI) is impaired microvascular perfusion due to embolization and obstruction of microcirculation with thrombus. Manual thrombectomy has the potential to reduce distal embolization and improve microvascular perfusion. Clinical trials have shown mixed results regarding thrombectomy.
OBJECTIVE: The …
Authors
Jolly SS; Cairns J; Yusuf S; Meeks B; Shestakovska O; Thabane L; Niemelä K; Steg PG; Bertrand OF; Rao SV
Journal
American Heart Journal, Vol. 167, No. 3, pp. 315–321.e1
Publisher
Elsevier
Publication Date
March 2014
DOI
10.1016/j.ahj.2013.12.002
ISSN
0002-8703