Vasomodulation of skeletal muscle BOLD signal

PURPOSE: To evaluate whether the BOLD signal from skeletal muscle can be modulated by exercise and ingestion of vasoactive substances. MATERIALS AND METHODS: The right calf muscles of healthy adult volunteers were imaged using a GE 1.5-Tesla scanner and a gradient-echo sequence with spiral readout. Time-varying changes in the BOLD signal were induced through cyclic phases of normoxia (90 seconds of 20.8% O2) and hyperoxia (45 seconds of 100% O2 …