Reduced muscle lactate during prolonged exercise following induced plasma volume expansion

To examine the effects of a dilutional mediated decrease in arterial O2 content on muscle metabolic and substrate behaviour during exercise, plasma volume was acutely expanded by either 14% (LOW) or 21% (HIGH) using a 6% dextran solution dissolved in saline (Macrodex) and compared with a control (CON) condition. The exercise protocol, performed by eight untrained males (VO2max = 45.2 +/- 2.2 mL.kg-1.min-1, X +/- SE) and with the conditions …