Journal article
PKM2 contributes to cancer metabolism
Abstract
Reprogramming of cell metabolism is essential for tumorigenesis, and is regulated by a complex network, in which PKM2 plays a critical role. PKM2 exists as an inactive monomer, less active dimer and active tetramer. While dimeric PKM2 diverts glucose metabolism towards anabolism through aerobic glycolysis, tetrameric PKM2 promotes the flux of glucose-derived carbons for ATP production via oxidative phosphorylation. Equilibrium of the PKM2 …
Authors
Wong N; Ojo D; Yan J; Tang D
Journal
Cancer Letters, Vol. 356, No. 2, pp. 184–191
Publisher
Elsevier
Publication Date
1 2015
DOI
10.1016/j.canlet.2014.01.031
ISSN
0304-3835