Long-Term Outcome After Resection of Non-Small Cell Lung Cancer Invading the Thoracic Inlet Academic Article uri icon

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abstract

  • BACKGROUND: The aim of this study was to update our previous experience and describe long-term results after resection of non-small-cell lung cancer (NSCLC) invading the thoracic inlet. METHODS: Patients from a single center undergoing resection of NSCLC invading the thoracic inlet were reviewed with data retrieved retrospectively from their charts. RESULTS: Sixty-five consecutive patients with a median age of 61 (32-76) years underwent resection of NSCLC invading the thoracic inlet from 1991 to 2011. Tumor location was divided into 5 anatomic zones from anterior to posterior. Fifty-two (80%) patients had induction therapy, mostly with 2 cycles of cisplatin-etoposide and 45 Gy of concurrent irradiation. All patients underwent at least first rib resection. Lobectomy was performed in 60 patients (92%). Twenty-four patients (37%) had vertebral resection. Arterial resections were performed in 7 patients (11%). Postoperative morbidity and mortality were 46% and 6%, respectively. Pathologic response to induction was complete (pCR) (n = 19) or nearly complete (pNR) (n = 12) in 31 patients (48%). Adjuvant treatment was administered in 14 (25%) patients. After a median follow-up of 20 (0-193) months, 34 patients are alive without recurrence. The overall 5-year survival reached 69%. Univariate analysis identified site of tumor within the thoracic inlet (p = 0.050), response to induction (p = 0.004), and presence of adjuvant treatment (p = 0.028) as survival predictors. CONCLUSIONS: Survival after resection of NSCLC invading the thoracic inlet in highly selected patients reached 69% at 5 years. Tumor location within the thoracic inlet, pathologic response to induction therapy, and adjuvant treatments were significant survival predictors.

authors

  • Collaud, Stéphane
  • Machuca, Tiago
  • Mercier, Olaf
  • Waddell, Thomas K
  • Yasufuku, Kazuhiro
  • Pierre, Andrew F
  • Darling, Gail E
  • Cypel, Marcelo
  • Rampersaud, Yoga R
  • Lewis, Stephen J
  • Shepherd, Frances A
  • Leighl, Natasha B
  • Cho, John BC
  • Bezjak, Andrea
  • Keshavjee, Shafique
  • de Perrot, Marc

publication date

  • September 2014