Journal article
Homocysteine-lowering trials for prevention of cardiovascular events: A review of the design and power of the large randomized trials
Abstract
BACKGROUND: Dietary supplementation with folic acid and vitamin B12 lowers blood homocysteine concentrations by about 25% to 30% in populations without routine folic acid fortification of food and by about 10% to 15% in populations with such fortification. In observational studies, 25% lower homocysteine has been associated with about 10% less coronary heart disease (CHD) and about 20% less stroke.
METHODS: We reviewed the design and …
Authors
Collaboration B-VTT
Journal
American Heart Journal, Vol. 151, No. 2, pp. 282–287
Publisher
Elsevier
Publication Date
2 2006
DOI
10.1016/j.ahj.2005.04.025
ISSN
0002-8703