Journal article
A dual CysLT1/2 antagonist attenuates allergen‐induced airway responses in subjects with mild allergic asthma
Abstract
BACKGROUND: The cysteinyl leukotrienes (cysLTs) play a key role in the pathophysiology of asthma. In addition to functioning as potent bronchoconstrictors, cysLTs contribute to airway inflammation through eosinophil and neutrophil chemotaxis, plasma exudation, and mucus secretion. We tested the activity of the dual cysLT1/2 antagonist, ONO-6950, against allergen-induced airway responses.
METHODS: Subjects with documented allergen-induced early …
Authors
Gauvreau GM; Boulet L; FitzGerald JM; Cockcroft DW; Davis BE; Leigh R; Tanaka M; Fourre JA; Tanaka M; Nabata T
Journal
Allergy, Vol. 71, No. 12, pp. 1721–1727
Publisher
Wiley
Publication Date
12 2016
DOI
10.1111/all.12987
ISSN
0001-5148