Effect of bromocriptine alginate nanocomposite (BANC) on the transgenic Drosophila model of Parkinson's disease
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abstract
The effect of bromocriptine alginate nanocomposite (BANC) was studied on Parkinson's disease (PD) model flies. The synthesized BANC was subject to characterization and at final concentration of 0.5, 1.0 and 1.5µM was mixed in diet. The PD flies were allowed to feed on it for 24 days. A significant dose dependent delay in the loss of climbing activity and activity pattern was observed in the PD flies exposed to 0.5, 1.0 and 1.5µM BANC. The PD flies exposed to BANC also showed a significant reduction in lipid peroxidation, glutathione-S- transferase activity and an increase in glutathione content. However, no gross morphological changes were observed in the brains of PD and control flies. The results suggest that BANC is effective in reducing the PD symptoms in transgenic flies.
