Journal article
Clinical benefit of intra-articular saline as a comparator in clinical trials of knee osteoarthritis treatments: A systematic review and meta-analysis of randomized trials
Abstract
OBJECTIVES: Hyaluronic acid and corticosteroids are common intra-articular (IA) therapies widely used for the management of mild to moderate knee osteoarthritis (OA). Many trials evaluating the efficacy of IA administered therapies commonly use IA saline injections as a placebo comparator arm. Using a systematic review and meta-analysis, our objective was to assess the clinical benefit associated with use of IA saline in trials of IA therapies …
Authors
Altman RD; Devji T; Bhandari M; Fierlinger A; Niazi F; Christensen R
Journal
Seminars in Arthritis and Rheumatism, Vol. 46, No. 2, pp. 151–159
Publisher
Elsevier
Publication Date
October 2016
DOI
10.1016/j.semarthrit.2016.04.003
ISSN
0049-0172