Viscosupplementation in Knee Osteoarthritis: Evidence Revisited

➢ The body of evidence surrounding the use of viscosupplementation in knee osteoarthritis is extensive and fraught with heterogeneous trials with conflicting conclusions.➢ Attempts to aggregate the evidence through systematic reviews, meta-analyses, and guidelines have also resulted in unclear, discordant recommendations. Closer examination reveals that the evidence around viscosupplementation favors clinically important reductions in pain among higher-molecular-weight and cross-linked formulations and is a safe option in patients with knee osteoarthritis.➢ Further large trials assessing the use of viscosupplementation across various formulations in knee osteoarthritis may confirm subgroup findings from meta-analyses; however, immediate focus on improved knowledge translation is required to ensure evidence-based approaches to the treatment of knee osteoarthritis.

Viscosupplementation in Knee Osteoarthritis: Evidence Revisited Journal Articles