Journal article
Modulatory effects of estrogen in two murine models of experimental colitis
Abstract
The association between oral contraceptives or pregnancy and inflammatory bowel disease is unclear. We investigated whether 17beta-estradiol modulates intestinal inflammation in two models of colitis. Female mice were treated with 17beta-estradiol alone or with tamoxifen, tamoxifen alone, 17 alpha-estradiol, or placebo. Dinitrobenzene sulfonic acid (DNB)- or dextran sodium sulfate (DSS)-induced colitis were assessed macroscopically, …
Authors
Verdú EF; Deng Y; Bercik P; Collins SM
Journal
AJP Gastrointestinal and Liver Physiology, Vol. 283, No. 1, pp. g27–g36
Publisher
American Physiological Society
Publication Date
July 1, 2002
DOI
10.1152/ajpgi.00460.2001
ISSN
0193-1857