Journal article
Hydrogen sulphide protects against NSAID‐enteropathy through modulation of bile and the microbiota
Abstract
BACKGROUND AND PURPOSE: Hydrogen sulphide is an important mediator of gastrointestinal mucosal defence. The use of non-steroidal anti-inflammatory drugs (NSAIDs) is significantly limited by their toxicity in the gastrointestinal tract. Particularly concerning is the lack of effective preventative or curative treatments for NSAID-induced intestinal damage and bleeding. We evaluated the ability of a hydrogen sulphide donor to protect against …
Authors
Blackler RW; Motta J; Manko A; Workentine M; Bercik P; Surette MG; Wallace JL
Journal
British Journal of Pharmacology, Vol. 172, No. 4, pp. 992–1004
Publisher
Wiley
Publication Date
February 2015
DOI
10.1111/bph.12961
ISSN
0007-1188