CELL-CYCLE CHARACTERISTICS - ALTERABLE DETERMINANTS OF REMISSION DURATION IN A STUDY OF 179 STANDARD RISK NEWLY DIAGNOSED PATIENTS WITH ACUTE MYELOID-LEUKEMIA Academic Article uri icon

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abstract

  • Prognostic factors were related to remission duration among 179 standard risk newly diagnosed acute myeloid leukemia (AML) patients who received identical induction and consolidation therapies. Following a bromodeoxyuridine infusion, labeling indices of bone marrow aspirate/biopsy, durations of S-phase and cell cycle (Tc) were determined. Patients with slowly cycling myeloblasts had longer remissions (Log rank p=0.03) than those with rapidly cycling myeloblasts. Multivariate analysis demonstrated that both WBC and Tc contributed to remission duration (p=0.01 and 0.005 respectively). Patients with slowly proliferating leukemias have longer remissions probably due to slower regrowth of leukemia between chemotherapy courses.

authors

  • RAZA, A
  • YOUSUF, N
  • BOKHARI, SA
  • ABBAS, A
  • LAMPKIN, B
  • PANCOAST, J
  • BISMAYER, J
  • SIEGRIST, C
  • Browman, George
  • BENNETT, J
  • GOLDBERG, J
  • GRUNWALD, H
  • LARSON, R
  • TRICOT, G
  • VOGLER, R
  • GARTSIDE, P
  • PREISLER, H

publication date

  • February 1993