Off-Pump Coronary Artery Bypass Surgery May Reduce the Incidence of Stroke in Patients with Significant Left Main Stem Disease Academic Article uri icon

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  • BACKGROUND: Off-pump coronary artery bypass (OPCAB) surgery in patients with left main stem (LMS) disease remains controversial. This meta-analysis compares early outcomes of OPCAB surgery with on-pump coronary artery bypass (ONCAB) surgery in patients with significant LMS disease, focusing on the outcomes stroke and transient ischemic attack (TIA). METHODS: This is a meta-analysis of non-randomized comparative peer-reviewed publications sourced from a systematic search of Embase, Medline, Cochrane, Google Scholar and CINAHL (1965-2007). A random effects model was used and heterogeneity was assessed. RESULTS: Nine studies (4411 patients) dating from 2000-2007, of whom 1036 (23.5 %) underwent OPCAB and 3375 (76.5 %) ONCAB, were included. The incidence of stroke was lower in the OPCAB group (OR 0.17 [95 % CI 0.05 to 0.60]). Early mortality, length of hospital stay, blood loss and inotropic requirements were significantly favored by OPCAB surgery. CONCLUSIONS: OPCAB may offer a neurological benefit in patients with significant LMS disease undergoing coronary artery bypass grafting.


  • Panesar, S
  • Chikwe, J
  • Mirza, S
  • Rahman, M
  • Warren, O
  • Rao, C
  • Negus, J
  • Zacharakis, E
  • Darzi, Andrea
  • Athanasiou, T

publication date

  • August 2008