Journal article
Intra-Operative Tissue Oxygen Tension Is Increased by Local Insufflation of Humidified-Warm CO2 during Open Abdominal Surgery in a Rat Model
Abstract
INTRODUCTION: Maintenance of high tissue oxygenation (PtO2) is recommended during surgery because PtO2 is highly predictive of surgical site infection and colonic anastomotic leakage. However, surgical site perfusion is often sub-optimal, creating an obstructive hurdle for traditional, systemically applied therapies to maintain or increase surgical site PtO2. This research tested the hypothesis that insufflation of humidified-warm CO2 into the …
Authors
Marshall JK; Lindner P; Tait N; Maddocks T; Riepsamen A; van der Linden J
Journal
PLOS ONE, Vol. 10, No. 4,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pone.0122838
ISSN
1932-6203