A Magnetically-Triggered Composite Membrane for On-Demand Drug Delivery Academic Article uri icon

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abstract

  • Nanocomposite membranes based on thermosensitive, poly(N-isopropylacrylamide)-based nanogels and magnetite nanoparticles have been designed to achieve "on-demand" drug delivery upon the application of an oscillating magnetic field. On-off release of sodium fluorescein over multiple magnetic cycles has been successfully demonstrated using prototype membrane-based devices. The total drug dose delivered was directly proportional to the duration of the "on" pulse. The membranes were non-cytotoxic, biocompatible, and retained their switchable flux properties after 45 days of subcutaneous implantation.

authors

  • Hoare, Todd Ryan
  • Santamaria, Jesus
  • Goya, Gerardo F
  • Irusta, Silvia
  • Lin, Debora
  • Lau, Samantha
  • Padera, Robert
  • Langer, Robert
  • Kohane, Daniel S