Developing a Risk-Model of Time to First-Relapse for Children and Adolescents With a Psychotic Disorder Academic Article uri icon

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abstract

  • Individuals treated for psychotic disorders and mood disorders with psychotic features have a high likelihood of relapse across the life course. This study examines the relapse rate and its associated predictors for children and adolescents experiencing a first-episode and develops a statistical risk-model for prediction of time to first-relapse. A multiyear, retrospective cohort design was used to track youth, under the age of 18 years, who experienced a first-episode of psychosis, and were admitted to 1 of 6 inpatient hospital psychiatric units (N = 87). Participants were followed for at least 2 years (M = 3.9, SD = 1.3) using survival analysis. Approximately 60% of subjects experienced relapse requiring hospital readmission by the end of follow-up, with 33% readmitted within the first year and 44% within 2 years. Median survival time was 34 months. Cox proportional hazards regression identified 4 key risk factors for relapse: medication nonadherence, female gender, receiving clinical treatment, and a decline in social support before first admission.

authors

  • Gearing, Robin Edward
  • Mian, Irfan
  • Sholonsky, Aron
  • Barber, Jim
  • Nicholas, David
  • Lewis, Ralph
  • Solomon, Leigh
  • Williams, Constance
  • Lightbody, Shawna
  • Steele, Margaret
  • Davidson, Brenda
  • Manchanda, Rahul
  • Joseph, Llewellyn
  • Handelman, Kenneth
  • Ickowicz, Abel

publication date

  • January 2009

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