Efficacy of a Targeted, Oral Penicillin–Based Yaws Control Program among Children Living in Rural South America Academic Article uri icon

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  • Yaws is endemic in rural Guyana. An observational study was conducted to determine the efficacy of oral penicillin V therapy in treating skin lesions of yaws in children. In 1999, inhabitants of 7 rural villages near Bartica, Guyana, were screened for skin lesions of yaws. Cases were confirmed by serological testing. A control program was implemented in 2000: children < or =14 years old were screened, and those with active lesions were treated with oral penicillin V for 7-10 days. In 2001, children were rescreened and active cases were treated. Prevalence of yaws skin lesions fell from 5.1% (52 of 1020 children screened in 2000) to 1.6% (8 of 516 in 2001), a 71% drop. Sixteen (94%) of 17 children treated in 2000 and reassessed in 2001 had complete resolution of lesions. A targeted, oral penicillin-based treatment regimen can successfully treat dermatologic yaws in individual children and can decrease the prevalence of skin yaws in a community in which it is endemic. This information may aid in the implementation of additional control efforts.


  • Scolnik, D
  • Aronson, L
  • Lovinsky, R
  • Toledano, K
  • Glazier, R
  • Eisenstadt, J
  • Eisenberg, P
  • Wilcox, Lindsay
  • Rowsell, R
  • Silverman, M

publication date

  • May 15, 2003