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Cholinergic Depletion in Alzheimer’s Disease Shown...
Journal article

Cholinergic Depletion in Alzheimer’s Disease Shown by [18F]FEOBV Autoradiography

Abstract

Rationale. Alzheimer's Disease (AD) is a neurodegenerative condition characterized in part by deficits in cholinergic basalocortical and septohippocampal pathways. [(18)F]Fluoroethoxybenzovesamicol ([(18)F]FEOBV), a Positron Emission Tomography ligand for the vesicular acetylcholine transporter (VAChT), is a potential molecular agent to investigate brain diseases associated with presynaptic cholinergic losses. Purpose. To demonstrate this …

Authors

Parent MJ; Bedard M-A; Aliaga A; Minuzzi L; Mechawar N; Soucy J-P; Schirrmacher E; Kostikov A; Gauthier SG; Rosa-Neto P

Journal

International Journal of Molecular Imaging, Vol. 2013, No. 1,

Publisher

Hindawi

Publication Date

November 10, 2013

DOI

10.1155/2013/205045

ISSN

2090-1712