Hemagglutinin Stalk Immunity Reduces Influenza Virus Replication and Transmission in Ferrets Academic Article uri icon

  •  
  • Overview
  •  
  • Research
  •  
  • Identity
  •  
  • Additional Document Info
  •  
  • View All
  •  

abstract

  • We assessed whether influenza virus hemagglutinin stalk-based immunity protects ferrets against aerosol-transmitted H1N1 influenza virus infection. Immunization of ferrets by a universal influenza virus vaccine strategy based on viral vectors expressing chimeric hemagglutinin constructs induced stalk-specific antibody responses. Stalk-immunized ferrets were cohoused with H1N1-infected ferrets under conditions that permitted virus transmission. Hemagglutinin stalk-immunized ferrets had lower viral titers and delayed or no virus replication at all following natural exposure to influenza virus.

authors

  • Nachbagauer, Raffael
  • Miller, Matthew S
  • Hai, Rong
  • Ryder, Alex B
  • Rose, John K
  • Palese, Peter
  • García-Sastre, Adolfo
  • Krammer, Florian
  • Albrecht, Randy A

publication date

  • March 15, 2016