Journal article
Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50 000 individuals
Abstract
BACKGROUND: Some countries fortify flour with folic acid to prevent neural tube defects but others do not, partly because of concerns about possible cancer risks. We aimed to assess any effects on site-specific cancer rates in the randomised trials of folic acid supplementation, at doses higher than those from fortification.
METHODS: In these meta-analyses, we sought all trials completed before 2011 that compared folic acid versus placebo, had …
Authors
Vollset SE; Clarke R; Lewington S; Ebbing M; Halsey J; Lonn E; Armitage J; Manson JE; Hankey GJ; Spence JD
Journal
The Lancet, Vol. 381, No. 9871, pp. 1029–1036
Publisher
Elsevier
Publication Date
3 2013
DOI
10.1016/s0140-6736(12)62001-7
ISSN
0140-6736