Journal article
Homocysteine induces mesangial cell apoptosis via activation of p38-mitogen-activated protein kinase
Abstract
Hyperhomocysteinemia is prevalent among patients with chronic kidney disease (CKD) and has been linked to progressive kidney and vascular diseases. Increased glomerular mesangial cell (MC) turnover, including proliferation and apoptosis, is a hallmark of CKD. Activation of p38-mitogen-activated protein kinase (p38-MAPK) has been linked to apoptosis in many cell lines. Accordingly, we studied the effect of homocysteine (Hcy) on MC p38-MAPK …
Authors
Shastry S; Ingram AJ; Scholey JW; James LR
Journal
Kidney International, Vol. 71, No. 4, pp. 304–311
Publisher
Elsevier
Publication Date
2 2007
DOI
10.1038/sj.ki.5002031
ISSN
0085-2538