Development of the Paris Definition of Early Crohnʼs Disease for Disease-Modification Trials: Results of an International Expert Opinion Process Academic Article uri icon

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  • We report the findings and outputs of an international expert opinion process to develop a definition of early Crohn's disease (CD) that could be used in future disease-modification trials. Nineteen experts on inflammatory bowel diseases held an international expert opinion meeting to discuss and agree on a definition for early CD to be used in disease-modification trials. The process included literature searches for the relevant basic-science and clinical evidence. A published preliminary definition of early CD was used as the basis for development of a proposed definition that was discussed at the expert opinion meeting. The participants then derived a final definition, based on best current knowledge, that it is hoped will be of practical use in disease-modification trials in CD.


  • Peyrin-Biroulet, Laurent
  • Billioud, Vincent
  • DʼHaens, Geert
  • Panaccione, Remo
  • Feagan, Brian
  • Panés, Julian
  • Danese, Silvio
  • Schreiber, Stefan
  • Ogata, Haruhiko
  • Hibi, Toshifumi
  • Higgins, Peter DR
  • Beaugerie, Laurent
  • Chowers, Yehuda
  • Louis, Edouard
  • Steinwurz, Flávio
  • Reinisch, Walter
  • Rutgeerts, Paul
  • Colombel, Jean-Frédéric
  • Travis, Simon
  • Sandborn, William J

publication date

  • December 2012