The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4 Journal Articles

abstract

• The inositol phosphatase, MTMR4 (myotubularin-related protein 4), was identified as a novel interactor of the ubiquitin ligase Nedd4 (neural-precursor-cell-expressed developmentally down-regulated 4). hMTMR4 (human MTMR4) and Nedd4 co-immunoprecipitated and co-localized to late endosomes. The PY (Pro-Tyr) motif of hMTMR4 binds to WW (Trp-Trp) domains of hNedd4. MTMR4 expression was decreased in atrophying muscle, whereas Nedd4 expression was increased and hMTMR4 was ubiquitinated by hNedd4, suggesting that this novel interaction may underlie the biological process of muscle breakdown.

authors

• Plant, Pamela J
• Correa, Judy
• Goldenberg, Neil
• Bain, James
• Batt, Jane

status

• published 

publication date

• April 1, 2009

has subject area

• 03 Chemical Sciences (FoR)
• 06 Biological Sciences (FoR)
• 11 Medical and Health Sciences (FoR)
• Animals (MeSH)
• Biochemistry & Molecular Biology (Science Metrix)
• Blotting, Western (MeSH)
• Cell Line (MeSH)
• Endosomal Sorting Complexes Required for Transport (MeSH)
• HeLa Cells (MeSH)
• Humans (MeSH)
• Immunoprecipitation (MeSH)
• Male (MeSH)
• Muscles (MeSH)
• Nedd4 Ubiquitin Protein Ligases (MeSH)
• Protein Binding (MeSH)
• Protein Structure, Tertiary (MeSH)
• Protein Tyrosine Phosphatases, Non-Receptor (MeSH)
• Rats (MeSH)
• Ubiquitin-Protein Ligases (MeSH)
• Ubiquitination (MeSH)

published in

• Biochemical Journal  Journal

keywords

• Animals
• Blotting, Western
• Cell Line
• Endosomal Sorting Complexes Required for Transport
• HeLa Cells
• Humans
• Immunoprecipitation
• Male
• Muscles
• Nedd4 Ubiquitin Protein Ligases
• Protein Binding
• Protein Structure, Tertiary
• Protein Tyrosine Phosphatases, Non-Receptor
• Rats
• Ubiquitin-Protein Ligases
• Ubiquitination

Digital Object Identifier (DOI)

• 10.1042/bj20081866

start page

• 57

end page

• 63

volume

• 419

issue

• 1