Journal article
The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4
Abstract
The inositol phosphatase, MTMR4 (myotubularin-related protein 4), was identified as a novel interactor of the ubiquitin ligase Nedd4 (neural-precursor-cell-expressed developmentally down-regulated 4). hMTMR4 (human MTMR4) and Nedd4 co-immunoprecipitated and co-localized to late endosomes. The PY (Pro-Tyr) motif of hMTMR4 binds to WW (Trp-Trp) domains of hNedd4. MTMR4 expression was decreased in atrophying muscle, whereas Nedd4 expression was …
Authors
Plant PJ; Correa J; Goldenberg N; Bain J; Batt J
Journal
Biochemical Journal, Vol. 419, No. 1, pp. 57–63
Publisher
Portland Press
Publication Date
April 1, 2009
DOI
10.1042/bj20081866
ISSN
0264-6021