Journal article
[1-Deamino-4-Cyclohexylalanine] Arginine Vasopressin: A Potent and Specific Agonist for Vasopressin V1b Receptors
Abstract
To date, there are no vasopressin (VP) agonists that exhibit a high affinity and selectivity for the VP V1b receptor with respect to the V1a, V2, and oxytocin receptors. In this study, we describe the synthesis and pharmacological properties of [1-deamino-4-cyclohexylalanine] arginine vasopressin (d[Cha4]AVP). Binding experiments performed on various membrane preparations revealed that d[Cha(4)]AVP exhibits a nanomolar affinity for V1b …
Authors
Derick S; Cheng LL; Voirol MJ; Stoev S; Giacomini M; Wo NC; Szeto HH; Mimoun MB; Andres M; Gaillard RC
Journal
Endocrinology, Vol. 143, No. 12, pp. 4655–4664
Publisher
The Endocrine Society
Publication Date
December 1, 2002
DOI
10.1210/en.2002-220363
ISSN
0013-7227