Journal article
TPI ASM8 reduces eosinophil progenitors in sputum after allergen challenge
Abstract
BACKGROUND: TPI ASM8 contains two modified phosphorothioate antisense oligonucleotides (AON), one targeting the common beta chain (βc) of the IL-3/IL-5/GM-CSF receptors and the other targeting the chemokine receptor CCR3. Inhalation of TPI ASM8 significantly improves lung function and sputum eosinophilia after allergen inhalation challenge in asthmatics.
OBJECTIVE: This study assessed whether TPI ASM8 reduces airway levels of haemopoietic …
Authors
Imaoka H; Campbell H; Babirad I; Watson RM; Mistry M; Sehmi R; Gauvreau GM
Journal
Clinical & Experimental Allergy, Vol. 41, No. 12, pp. 1740–1746
Publisher
Wiley
Publication Date
December 2011
DOI
10.1111/j.1365-2222.2011.03816.x
ISSN
0954-7894