Journal article
Maternal allergy modulates cord blood hematopoietic progenitor Toll-like receptor expression and function
Abstract
BACKGROUND: Little is known regarding the prenatal determinants of innate immune responses in relation to infant allergic risk. Environmental exposures, including microbial stimuli, might predispose susceptible subjects to atopy and asthma in early infancy or even in utero.
OBJECTIVE: Because Toll-like receptors (TLRs) recognize microbial products and because cord blood (CB) progenitor alterations have been observed in neonates at risk for …
Authors
Reece P; Thanendran A; Crawford L; Tulic MK; Thabane L; Prescott SL; Sehmi R; Denburg JA
Journal
Journal of Allergy and Clinical Immunology, Vol. 127, No. 2, pp. 447–453
Publisher
Elsevier
Publication Date
February 2011
DOI
10.1016/j.jaci.2010.11.006
ISSN
0091-6749