Immunization Strategies Against Pulmonary Tuberculosis: Considerations of T Cell Geography

Pulmonary tuberculosis (TB) remains a global health concern with an astounding 9 million new cases and 2 million deaths per year. This leading infectious cause of death remains highly prevalent with one third of the world’s population latently infected with Mycobacteriumtuberculosis(M.tb) despite routine vaccination against TB in endemic areas. The only approved TB vaccine is the Bacille Calmette-Guerin (BCG), which provides protection against …