Journal article
U46619-induced bronchoconstriction in asthmatic subjects is mediated by acetylcholine release.
Abstract
Thromboxane A2 (TxA2) has been implicated in the pathogenesis of airway hyperresponsiveness. U46619 is a chemical that mimics the effects of TxA2. Both TxA2 and U46619 have been demonstrated to act presynaptically to enhance the release of acetylcholine from cholinergic nerves in canine airway smooth muscle. The purpose of this study was to determine whether the bronchoconstriction caused by inhaled U46619 in asthmatic subjects is caused by …
Authors
Saroea HG; Inman MD; O'Byrne PM
Journal
American Journal of Respiratory and Critical Care Medicine, Vol. 151, No. 2, pp. 321–324
Publisher
American Thoracic Society
Publication Date
February 1995
DOI
10.1164/ajrccm.151.2.7842185
ISSN
1073-449X
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidAcetylcholineAdolescentAdultAsthmaBronchial Provocation TestsBronchoconstrictionCross-Over StudiesDouble-Blind MethodFemaleHumansIpratropiumMaleMethacholine ChlorideProstaglandin Endoperoxides, SyntheticThromboxane A2Vasoconstrictor Agents