Journal article
Enhanced cell volume regulation: a key protective mechanism of ischemic preconditioning in rabbit ventricular myocytes
Abstract
Accumulation of osmotically active metabolites, which create an osmotic gradient estimated at ~60 mOsM, and cell swelling are prominent features of ischemic myocardial cell death. This study tests the hypothesis that reduction of ischemic swelling by enhanced cell volume regulation is a key mechanism in the delay of ischemic myocardial cell death by ischemic preconditioning (IPC). Experimental protocols address whether: (i) IPC triggers a cell …
Authors
Diaz RJ; Armstrong SC; Batthish M; Backx PH; Ganote CE; Wilson GJ
Journal
Journal of Molecular and Cellular Cardiology, Vol. 35, No. 1, pp. 45–58
Publisher
Elsevier
Publication Date
January 2003
DOI
10.1016/s0022-2828(02)00277-8
ISSN
0022-2828