Central Venous Line Dysfunction is an Independent Predictor of Poor Survival in Children With Cancer

Central venous line (CVL) dysfunction (mainly from thrombotic occlusion) is a frequent, but relatively less-studied complication compared with infection and thromboembolism (TE). In adults with cancer, TE results in poor outcome. We evaluated the impact of CVL-dysfunction and TE on overall survival (OS) and event-free survival (EFS) in children with noncentral nervous system cancer (n=358). CVL-dysfunction was defined as persistent or recurrent …