The UNSIN Project: Exploring the Molecular Physiology of Sins

Students in a first year undergraduate biology course explored the molecular underpinnings of human misbehavior. 181 students were divided into 18 groups, randomly allotted to deal with one of the four deadly sins—Sloth, Gluttony, Lust and Wrath. Students were expected to read primary sources to devise molecular ways to counter these sins. Group progress was monitored over the 12 week period by the preceptor (PKR) at scheduled intervals. A single randomly selected student was questioned about the work done, and future directions were provided by the preceptor. At term's end, randomly selected students defended their group's approaches to the entire class. A final written report was graded. The molecules explored by different groups included dopamine, serotonin, ghrelin, testosterone, CGRP amongst others. Based on student comments, the project provided a valuable learning experience (8.87±1.46, n=156) and the random selection approach gave students a greater sense of responsibility to their group (8.08±2.31, n=154). Furthermore, it enabled students to hone their skills at searching, synthesizing, sharing and presenting information, fostered group interactions, and provided a solid knowledge base for subsequent courses.