Exploring the Virchow-Robin spaces function: A unified theory of brain diseases. Journal Articles uri icon

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abstract

  • BACKGROUND: Cerebrospinal fluid (CSF) transport across the central nervous system (CNS) is no longer believed to be on the conventional lines. The Virchow-Robin space (VRS) that facilitates CSF transport from the basal cisterns into the brain interstitial fluid (ISF) has gained interest in a whole new array of studies. Moreover, new line of evidence suggests that VRS may be involved in different pathological mechanisms of brain diseases. METHODS: Here, we review emerging studies proving the feasible role of VRS in sleep, Alzheimer's disease, chronic traumatic encephalopathy, and traumatic brain injury (TBI). RESULTS: In this study, we have outlined the possible role of VRS in different pathological conditions. CONCLUSION: The new insights into the physiology of the CSF circulation may have important clinical relevance for understanding the mechanisms underlying brain pathologies and their cure.

authors

  • Cherian, Iype
  • Beltran, Margarita
  • Kasper, Ekkehard
  • Bhattarai, Binod
  • Munokami, Sunil
  • Grasso, Giovanni

publication date

  • 2016