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Journal article

Do corticosteroids play a role in the management of traumatic brain injury?

Abstract

Neuroprotective strategies for the medical management of traumatic brain injury (TBI) have been elusive. While laboratory studies provide a conceptual framework for the potential efficacy of corticosteroids in this context, clinical trials testing this hypothesis have yielded no convincing evidence of clinical benefit. Here, we review the five key randomized control trials (RCTs) that have examined this issue. Based on the proposed primary endpoints of these RCTs, the five RCTs consistently showed that corticosteroids do not confer significant benefit in the TBI population.

Authors

Hoshide R; Cheung V; Marshall L; Kasper E; Chen CC

Journal

Surgical Neurology International, Vol. 7, No. 1,

Publisher

Scientific Scholar

Publication Date

January 1, 2016

DOI

10.4103/2152-7806.190439

ISSN

2229-5097

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