Bilirubin and its Oxidation Products Damage Brain White Matter

Abstract

Brain injury after intracerebral hemorrhage (ICH) occurs in cortex and white matter and may be mediated by blood breakdown products, including hemoglobin and heme. Effects of blood breakdown products, bilirubin and bilirubin oxidation products, have not been widely investigated in adult brain. Here, we first determined the effect of bilirubin and its oxidation products on the structure and function of white matter in vitro using brain slices. …

Authors

Lakovic K; Ai J; D'Abbondanza J; Tariq A; Sabri M; Alarfaj AK; Vasdev P; Macdonald RL

Journal

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 34, No. 11, pp. 1837–1847