Bleeding And Clotting Disorders In Pediatrics

The neonatal and pediatric stage is a period of rapid physiologic changes, some of which affect the hemostatic system. The hemostatic system is a dynamic system that evolves gradually from birth into the mature adult form. Evaluation of bleeding and clotting disorders in children requires an understanding of the evolution of physiologic normal values for age, the congenital disorders that present in early life, and the clinical settings common in childhood that affect hemostasis and thrombosis risks. The rapid evolution of the blood coagulation system after birth leads to a dynamic group of age-dependent reference ranges for the levels of the various components that should be considered physiologically normal.