Journal article
Impact of Antibiotic Duration on Gut Microbiome Composition and Antimicrobial Resistance: A Substudy of the BALANCE Randomized Controlled Trial
Abstract
Background: Maintaining a diverse gut microbiome and minimizing antimicrobial resistance gene (ARG) carriage through reduced antibiotic utilization may decrease antimicrobial resistance. We compared gut microbiome disruption and ARG carriage following 7 or 14 days of antibiotics for treatment of bacteremia in a substudy of the BALANCE randomized controlled trial.
Methods: The BALANCE randomized controlled trial enrolled 3631 participants with …
Authors
Armstrong E; Kulikova M; Yee N; Rishu A; Muscedere J; Sibley S; Maslove D; Boyd JG; Evans G; Detsky M
Journal
Open Forum Infectious Diseases, Vol. 12, No. 3,
Publisher
Oxford University Press (OUP)
Publication Date
February 28, 2025
DOI
10.1093/ofid/ofaf137
ISSN
2328-8957