Principles of optimal multidisciplinary management of prostate cancer in clinical practice

Advances in the diagnosis and management of prostate cancer have significantly changed the disease landscape. While benefiting from better oncological outcomes, patients are now experiencing higher rates of non-cancer comorbidities, including cardiovascular disease. The increasing impact of cardiovascular disease in those with prostate cancer led to the expanding role of cardio-oncology professionals in enhancing the multidisciplinary care of these patients. As a result, the International Cardio-Oncology Society (IC-OS) launched a 4-webinar series in collaboration with the European Association of Urology and the Canadian Urology Association to inform best practices in the multidisciplinary care of patients with prostate cancer. This program highlighted currently recommended diagnostic and treatment strategies from urology, oncology, and cardiology and emphasized knowledge gaps and future directions. In this article, which is the second in a 2-part series, we review challenging cases that were presented and discussed among a multidisciplinary international panel and highlight ongoing research and future directions from both urology/oncology and cardio-oncology.