Journal article
zol and fai: large-scale targeted detection and evolutionary investigation of gene clusters
Abstract
Many universally and conditionally important genes are genomically aggregated within clusters. Here, we introduce fai and zol, which together enable large-scale comparative analysis of different types of gene clusters and mobile-genetic elements, such as biosynthetic gene clusters (BGCs) or viruses. Fundamentally, they overcome a current bottleneck to reliably perform comprehensive orthology inference at large scale across broad taxonomic …
Authors
Salamzade R; Tran PQ; Martin C; Manson AL; Gilmore MS; Earl AM; Anantharaman K; Kalan LR
Journal
Nucleic Acids Research, Vol. 53, No. 3,
Publisher
Oxford University Press (OUP)
Publication Date
January 24, 2025
DOI
10.1093/nar/gkaf045
ISSN
0305-1048