An optical coherence tomography study of a photoactive Pt( iv ) prodrug in oesophageal tissue

Photoactive diazido Pt(iv) complexes display in vivo anticancer efficacy towards oesophageal tumours, a worldwide common cancer. Here we explore the use of optical coherence tomography (OCT) as a new method for detecting tissue penetration and damage produced by the photoactivatable anticancer complex trans,trans,trans-[Pt(pyridine)₂(N₃)₂(OH)₂] (FM190). Dehydration of the sample and a change in refractive index were observed for swine …