Lung Dose, Distribution, and Clinical Response to Therapeutic Aerosols

The response to therapeutic aerosols is considered to be a function of the dose deposited at the target site in the lung. The dose, in turn, is dependent upon the system producing the aerosol, the particle size characteristics of the inhaled aerosol, the mode of inhalation, and the calibre of the airways. The influence of the pattern of deposition of the inhaled dose, i.e., selective delivery to the central vs. small, peripheral airways, on the …