Journal article
Automated high throughput nucleic acid purification from formalin-fixed paraffin-embedded tissue samples for next generation sequence analysis
Abstract
Curation and storage of formalin-fixed, paraffin-embedded (FFPE) samples are standard procedures in hospital pathology laboratories around the world. Many thousands of such samples exist and could be used for next generation sequencing analysis. Retrospective analyses of such samples are important for identifying molecular correlates of carcinogenesis, treatment history and disease outcomes. Two major hurdles in using FFPE material for …
Authors
Haile S; Pandoh P; McDonald H; Corbett RD; Tsao P; Kirk H; MacLeod T; Jones M; Bilobram S; Brooks D
Journal
PLOS ONE, Vol. 12, No. 6,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pone.0178706
ISSN
1932-6203