Journal article
ZIC1 is a context-dependent medulloblastoma driver in the rhombic lip
Abstract
Transcription factors are frequent cancer driver genes, exhibiting noted specificity based on the precise cell of origin. We demonstrate that ZIC1 exhibits loss-of-function (LOF) somatic events in group 4 (G4) medulloblastoma through recurrent point mutations, subchromosomal deletions and mono-allelic epigenetic repression (60% of G4 medulloblastoma). In contrast, highly similar SHH medulloblastoma exhibits distinct and diametrically opposed …
Authors
Lee JJY; Tao R; You Z; Haldipur P; Erickson AW; Farooq H; Hendriske LD; Abeysundara N; Richman CM; Wang EY
Journal
Nature Genetics, Vol. 57, No. 1, pp. 88–102
Publisher
Springer Nature
Publication Date
January 2025
DOI
10.1038/s41588-024-02014-z
ISSN
1061-4036