Longitudinal Laboratory and Clinical Outcomes in Vaccine-Induced Immune Thrombotic Thrombocytopenia after 3 Years

Introduction: Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare yet severe complication that occurs 5 - 30 days after adenoviral vector-based vaccines against SARS-CoV-2. Patients with VITT present with thrombocytopenia and venous or arterial thrombosis, in unusual locations such as cerebral venous sinus thrombosis (CVST). The pathophysiology of VITT involves the generation of antibodies against platelet factor 4 (PF4, CXCL4), …