Chromosomal Instability as a Prognostic Biomarker for Local Failure in Laryngeal Carcinoma Patients Treated with Definitive Radiation in NRG/RTOG 9512

Purpose/Objective(s) Chromosomal instability (CIN) is an ongoing rate of chromosome missegregation events over the course of multiple cell divisions and is common in cancer. There appears to be a range of CIN that allows for optimal tumor cell fitness, and when increased beyond a maximally tolerated threshold, can lead to cell death due to loss of both copies of one or more essential chromosomes. Radiation induces CIN and we have shown that …