Journal article
Hemochromatosis neural archetype reveals iron disruption in motor circuits
Abstract
Our understanding of brain iron regulation and its disruption in disease is limited. Excess iron affects motor circuitry, contributing to Parkinson's disease (PD) risk. The molecular mechanisms regulating central iron levels, beyond a few well-known genes controlling peripheral iron, remain unclear. We generated scores based on the archetypal brain iron accumulation observed in magnetic resonance imaging scans of individuals with excessive …
Authors
Loughnan R; Ahern J; Boyle M; Jernigan TL; Hagler DJ; Iversen JR; Frei O; Smith DM; Andreassen O; Zaitlen N
Journal
Science Advances, Vol. 10, No. 47,
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
November 22, 2024
DOI
10.1126/sciadv.adp4431
ISSN
2375-2548