Simultaneous evaluation of the imprecision and inconsistency domains of GRADE can be performed using prediction intervals

OBJECTIVES: To explore the use of prediction interval (PI) for the simultaneous evaluation of the imprecision and inconsistency domains of Grading of Recommendations, Assessment, and Evaluation using stakeholder-provided decision thresholds. STUDY DESIGN AND SETTING: We propose transforming the PI of a meta-analysis from a relative risk scale to an absolute risk difference using an appropriate baseline risk. The transformed PI is compared to …